Intracytoplasmic Sperm Injection
Intracytoplasmic Sperm Injection (ICSI)
Intracytoplasmic Sperm Injection (ICSI)
Intracytoplasmic Sperm Injection (ICSI) is an advanced micromanipulation technique in assisted reproductive technology (ART) where a single sperm is directly injected into the cytoplasm of an egg (oocyte). This method facilitates fertilization, especially in cases where sperm cannot naturally penetrate the egg’s outer layer due to various factors.
Our Bebefits
Who Can Benefit from ICSI?
Male Factor Infertility
Men with low sperm count, poor sperm motility, or abnormal sperm morphology.
Obstructive Azoospermia
Blockages in the male reproductive tract preventing sperm ejaculation.
Fertilization Failures
Couples who have experienced unsuccessful fertilization in prior IVF cycles.
Surgically Retrieved Sperm
When utilizing sperm obtained through procedures like Testicular Sperm Aspiration (TESA) or from cryopreserved samples.
Egg-Related Factors
Cases involving poor oocyte quality, in vitro matured (IVM) eggs, or the use of frozen eggs.
Genetic Testing
Couples planning to perform Preimplantation Genetic Testing (PGT) on embryos.
Our Process
The Intracytoplasmic Sperm Injection (ICSI) Procedure
Ovarian Stimulation and Egg Retrieval:
- The female partner undergoes hormonal stimulation to encourage the development of multiple ovarian follicles.
- Monitoring through ultrasounds and blood tests ensures optimal follicle growth.
- Once follicles reach the desired size, a trigger injection is administered to induce final oocyte maturation.
- Approximately 36 hours post-trigger, egg retrieval is performed under sedation or anesthesia using ultrasound-guided aspiration.
Sperm Collection and Preparation:
- A semen sample is collected from the male partner on the day of egg retrieval.
- The sample is processed to isolate motile and morphologically normal sperm.
Micromanipulation and Fertilization:
- In the laboratory, a single sperm is selected and injected directly into the cytoplasm of each mature egg using a fine micropipette.
- Injected eggs are then cultured in specialized incubators under controlled conditions.
Embryo Development and Transfer:
- Fertilization is assessed the following day.
- Successfully fertilized eggs (embryos) are cultured for several days to monitor development.
- Depending on embryo quality and patient-specific factors, one or more embryos are selected for transfer into the uterus.
Potential Side Effects and Considerations
- Ovarian Hyperstimulation Syndrome (OHSS): A possible response to ovarian stimulation, characterized by swollen, painful ovaries.
- Procedure-Related Discomfort: Mild abdominal tenderness or spotting may occur post-egg retrieval.
- Anesthesia Effects: Temporary side effects such as dizziness, nausea, or vomiting.
Frequently Asked Questions (FAQs) About IVF
ICSI (Intracytoplasmic Sperm Injection) is a specialized form of in vitro fertilization (IVF) where a single sperm is injected directly into an egg to facilitate fertilization. Unlike conventional IVF, which relies on natural sperm-egg interaction, ICSI bypasses this process, making it ideal for cases with male fertility issues.
ICSI is recommended for couples facing male infertility factors, including low sperm count, poor sperm motility, or abnormal morphology. It’s also suitable for cases involving obstructive azoospermia, prior fertilization failures, or those using frozen or surgically retrieved sperm.
ICSI offers high success rates, especially for couples with male infertility issues. However, outcomes depend on several factors, such as the quality of eggs, sperm, and the age of the female partner. Your doctor can provide specific insights based on your unique case.
While ICSI is a safe procedure, it may carry some risks, such as ovarian hyperstimulation syndrome (OHSS) due to hormonal stimulation or minor discomfort from egg retrieval. Your fertility specialist will discuss these in detail to ensure you understand the process.
Yes, ICSI may be used for unexplained infertility if previous IVF attempts have not resulted in successful fertilization. Your doctor will evaluate your case to determine if ICSI is the best approach.
While there is a slightly higher risk of certain genetic abnormalities, especially if male infertility is genetic, Preimplantation Genetic Testing (PGT) can help identify any potential risks before embryo transfer. Genetic counseling is also available for couples with concerns.
The ICSI process, including ovarian stimulation, egg retrieval, fertilization, and embryo transfer, generally takes about 4-6 weeks. However, this can vary depending on individual response to treatment and specific protocols.
Our Commitment to Your Success
At Ferticare IVF Assist, our experienced team provides personalized care throughout the ICSI process, ensuring the highest standards of safety and support.